Chlorphenamine maleate
Chlorphenamine maleate
CLINICAL USE
Antihistamine:
Relief of allergy, pruritus Treatment/prophylaxis of anaphylaxis DOSE IN NORMAL RENAL FUNCTION
Oral: 4 mg 4–6 times a day (maximum 24 mg/day)IV/IM/SC: 10–20mg (maximum 40 mg/day) PHARMACOKINETICS
Molecular weight :390.9 %Protein binding :Approx 70 %Excreted unchanged in urine : Approx 22 Volume of distribution (L/kg) :3half-life – normal/ESRD (hrs) :12–43/– DOSE IN RENAL IMPAIRMENT
GFR (mL/MIN)
20 to 50 : Dose as in normal renal function 10 to 20 : Dose as in normal renal function <10 : Dose as in normal renal function. See ‘Other Information’ DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES
CAPD :Not dialysed. Dose as in normal renal function HD :Dialysed. Dose as in normal renal functionHDF/high flux :Dialysed. Dose as in normal renal functionCAV/VVHD :Dialysed. Dose as in normal renal function IMPORTANT DRUG INTERACTIONS
Potentially hazardous interactions with other drugsInhibits phenytoin metabolism and can lead to phenytoin toxicity ADMINISTRATION
Reconstition
– Route
Oral, IV Rate of Administration Bolus over 1 minute Comments
Injection reported to cause stinging or burning sensation at site of injection OTHER INFORMATION
Increased cerebral sensitivity in patients with renal impairment
See how to identify renal failure stages according to GFR calculation
See how to diagnose irreversible renal disease
Home
